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Gardel, Margaret
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overview My lab is dedicated to understanding how cell adhesion and migration is regulated by the physical behaviors and structure of the actin cytoskeleton, focal adhesions and cell-cell adhesions and how the physical behaviors of complex cytoskeletal machines emerge from their molecular constituents. We employ approaches from condensed matter physics, cell biology and biochemistry to study the physical properties of the actin cytoskeleton and focal adhesions within live cells and in reconstituted systems of purified proteins.
One or more keywords matched the following items that are connected to Gardel, Margaret
Item TypeName
Concept Focal Adhesions
Concept Focal Adhesion Kinase 1
Concept Focal Adhesion Kinase 2
Academic Article Myosin II-mediated focal adhesion maturation is tension insensitive.
Academic Article Optimization of traction force microscopy for micron-sized focal adhesions.
Academic Article Mechanical integration of actin and adhesion dynamics in cell migration.
Academic Article Biophysics. Clutch dynamics.
Academic Article Spatiotemporal constraints on the force-dependent growth of focal adhesions.
Academic Article Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension.
Academic Article Stressing the limits of focal adhesion mechanosensitivity.
Academic Article Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly.
Academic Article Preparation of complaint matrices for quantifying cellular contraction.
Academic Article Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed.
Academic Article Protrusive activity guides changes in cell-cell tension during epithelial cell scattering.
Academic Article Tension is required but not sufficient for focal adhesion maturation without a stress fiber template.
Academic Article PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
Grant Mechanical Regulation of Cell Adhesion by Dynamic Cytoskeletal Assemblies
Academic Article Machine learning interpretable models of cell mechanics from protein images.
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  • Focal Adhesions